99m-Tc Instant Kits
99mTc has a half-life of just 6 h. This makes it adventageous for nuclear medical clinics to prepare 99mTc radiopharmaceuticals themselves from so-called "instant kits." These kits contain all substances needed for the production of the preparation, such as ligands, reducing agents and stabilizers. These kits are, of course, lyophilized, pyrogen-free and sterile. Before injection, a 99mTcO4- solution from a commercial 99Mo/99mTc isotope generator is added.
Typical instant kit for preparing a 99mTc radiopharmaceutical |
Contents of 99mTc instant kits and their function |
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Ligand for complexing the metal e.g. hydroxycarboxylic acids, aminocarboxylic acids, phosphines, isonitriles, meraptoacetyltriglycine, aminooximes, mercaptoamides Note: links will open in a new browser window. |
in vivo distribution of the pharmaceutical |
| Reducing agent (e.g. SnCl2, sodium dithionite) |
Reduction of pertechnetate | |
| Stabilizers, catalysts (e.g. pH buffers, ascorbic acid) |
Reproducible reaction conditions | |
